赵灵芝,女,博士,副教授,1985年1月生。2012年6月在中国科学院化学研究所活体分析化学实验室获理学博士学位;2007年6月在陕西师范大学化学与材料科学学院获理学学士学位。2012年7月在陕西省西安医学院药学院就职。入职至今主持获批各级项目4项,参与各级项目8项。发表科研论文20余篇,以第一作者发表19篇,SCI收录5篇,ISTP收录1篇,CSCD收录7篇,其余均为核心。并担任SCI杂志“Electrochimica Acta”审稿人。任职以来,主要担任了本科《医用化学》、《有机化学》、和《基础化学》3门课程理论和实验教学。研究领域或方向主要为:(1)体内药物电化学分析研究;(2)细胞内活性物质电化学分析研究;(3)微型生物传感器研制;(4)纳米材料的生物兼容性研究以及药物的细胞毒理学研究等。。
发表的主要论文:
1. Lingzhi Zhao,Liu Zhao, Yanqing Miao, Chenxiao Zhang,Selective electrochemical determination of glutathione from the leakage of intracellular GSH contents in HeLa cells following doxorubicin-induced cell apoptosis, Electrochimica Acta. 2016, 206,86-98.(SCI,影响因子:4.806)
2. Lingzhi Zhao,Congcong Li, Honglan Qi, Qiang Gao, Chengxiao Zhang, Electrochemical lectin-based biosensor array for detection and discrimination of carcinoembryonic antigen using dual amplification of gold nanoparticles and horseradish peroxidase[J]. Sensors & Actuators B Chemical, 2016, 235:575-582.(SCI,影响因子:4.758)
3. Lingzhi Zhao,Liu Zhao, Yanqing Miao, Chunye Liu, Chenxiao Zhang,Construction of a Turn off-on-off Fluorescent System Based on Competitive Coordination of Cu2+ between 6, 7-Dihydroxycoumarin and Pyrophosphate Ion For Sensitive Assay of Pyrophosphatase Activity, Journal of Analytical Methods in Chemistry, 2016,accepted(SCI,影响因子:1. 369)
4. Lingzhi Zhao, Zhao Li, Liu Zhao, Yali Du, Chenxiao Zhang, In Vivo Determination of Reduced Thiols in Rat Cerebellum Paraflocculus following Salicylate-Induced Tinnitus by Fluorescence, Analytical letters, 2016(SCI,影响因子:1.036)
5. Lingzhi Zhao, Xianchan Li, Yuqing Lin, Lifen Yang, Ping Yu, Lanqun Mao, Electrochemical impedance spectroscopic measurements of FCCP-induced change in membrane permeability of MDCK cells, Analyst, 2012, 137, 2199–2204(SCI,影响因子:4.107)
6. Ying Shen,Lingzhi Zhao,Li Qi, Juan Qiao,Lanqun Mao, Yi Chen, Reactive Polymer as a Versatile Toolbox for Construction of Multifunctional Superparamagnetic Nanocomposites,Chemistry-A European Journal, 2012, 18, 13755(SCI,影响因子:5.731)
7. Zipin Zhang,Lingzhi Zhao, Yuqing Lin, Ping Yu, and Lanqun Mao, Online Electrochemical Measurements of Ca2+and Mg2+in Rat Brain Based on Divalent Cation Enhancement toward Electrocatalytic NADH Oxidation,Anal. Chem., 2010 ,82, 9885–9891(SCI,影响因子:5.886)
8. Xianchan Li,Lingzhi Zhao, Zhenling Chen, Yuqing Lin, Ping Yu, Lanqun Mao, Continuous Electrochemical Monitoring of Extracellular Lactate Production from Neonatal Rat Cardiomyocytes following Myocardial Hypoxia. Anal. Chem., 2012, 84 (12), 5285–529(SCI,影响因子:5.886)
9. Juan Qiao, Li Qi, Ying Shen,Lingzhi Zhao, Cui Qi, Dihua Shangguan, Lanqun Mao, Yi Chen, Thermal responsive fluorescent block copolymer for intracellular temperature sensing,J. Mater. Chem., 2012, 22, 11543-11549.(SCI,影响因子:4.263)
10. Yuqing Lin, Zipin Zhang,Lingzhi Zhao, XiangWang, Ping Yu, Lei Su, Lanqun Mao, A non-oxidative electrochemical approach to online measurements of dopamine release through laccase-catalyzed oxidation and intramolecular cyclization of dopamine, Biosensors and Bioelectronics, 2010, 25,1350–135(SCI,影响因子:7.409)
11.毛兰群、赵灵芝、杨丽芬,一种基于原电池的电化学传感器及其制备方法,201110220596.2,2011.8.03.(专利)
12. Lingzhi Zhao,Liu Zhao, Yanqing Miao, Chunye Liu, Colorimetric Sensing of Cysteine in serum by the competitive adsorption toward AuNPs between Cysteine and ATP,International Conference on Material, Mechanical and Manufacturing Engineering. 2015.(ISTP收录)
13.赵灵芝,张小清,苗延青,等. PDDA/MWNT自组装膜修饰碳纤维微电极选择性测定多巴胺的研究[J].化工新型材料, 2014(9).( CSCD源)
主持的科研项目:
(1)国家自然科学基金(青年项目)(项目编号:21305109),基于微流控芯片活细胞水平抗肿瘤效评价新方法研究。
(22万)
(2)陕西省科学技术厅自然科学基础研究计划项目(项目编号:2014JQ2073),活细胞水平抗肿瘤药效评价新方法研究。
(3万)
(3)博士科研启动基金(项目编号:2012 Doc 09),基于分子印迹技术抗高血糖药物体内分析新方法研究。(2万)
(4) 2013年省级大学生创新创业项目(项目编号:1746)(0.5万)
参与的科研项目:
(1)国家优秀青年项目(项目编号:21522504),生物电分析研究(150万)
(2)国家自然科学基金(项目编号:91132708),情感和记忆过程中生理活性分子的活体电化学分析(80万)
(3)国家自然科学基金(项目编号:81302706),RGD肽修饰的高稳谷胱甘肽(GSH)响应型胶团的构建与靶向机制研究
(23万)
(4)国家基自然科学金委面上项目(项目编号:21175141),基于配位聚合物的活体在线电分析化学新原理、新方法的研究。(60万元)
(5)国家自然科学基金委科学部主任基金(项目编号:21045001),基于醌与金属离子相互作用的电化学分析方法研究。(10万元)
(6)陕西省教育厅科研计划项目(项目编号:2013JK0759),载阿霉素(DOX)酸敏感型胶团的构建及其控释过程研究
(2万).
(7)陕西省科技厅科研计划项目(项目编号:2014K02-11-01),功能物质提取、工艺优化与产品开发:酸枣仁总皂苷的提取研究。(7万)
(8)西安市科技局的项目(项目编号:CXY1348(5)),五味子化学性肝损伤辅助保护功能研究。(6万)