何 昊
来源:药物研究所 作者:药物研究所管理员 点击数: 发表时间:2016-11-15 15:20:51

,男,毕业于沈阳药科大学,获药学博士学位,博士论文获得沈阳药科大学优秀博士学位论文。熟悉药理学和天然药物化学研究方法及过程,主要从事天然药物相关研究,天然产物活性成分提取分离,天然产物活性及作用机理研究。近年来发表相关科研论文20余篇,其中SCI收载16篇。

发表的主要论文:

1Hao He, Yong-sheng Feng, Ling-he Zang, Wei-wei Liu, Li-qin Ding, Li-xia Chen, Ning Kang, Toshihiko Hayashi, Shin-ichi Tashiro, Satoshi Onodera, Feng Qiu*, Takashi Ikejima*, Nitric oxide induces apoptosis and autophagy; autophagy down-regulates NO synthesis in physalin A-treated A375-S2 human melanoma cells, Food and Chemical Toxicology, 2014, 71: 128-135.

2. Hao He, Ling-he Zang, Yong-sheng Feng, Wei-wei Liu, Li-xia Chen, Ning Kang, Shin-ichi Tashiro, Satoshi Onodera, Feng Qiu*, Takashi Ikejima*. Physalin A Induces Apoptotic Cell Death and Protective Autophagy in HT1080 Human Fibrosarcoma Cells. Journal of Natural Products. 2013, 76(5): 880-888.

3. Hao He, Ling-he Zang, Yong-sheng Feng, Li-xia Chen, Ning Kang, Shin-ichi Tashiro, Satoshi Onodera, Feng Qiu*, Takashi Ikejima*. Physalin A induces Apoptosis via P53-Noxa-mediated ROS Generation, and Autophagy Plays a Protective Role against Apoptosis Through P38-NF-κB Survival Pathway in A375-S2 Cells.Journal of Ethnopharmacology.2013, 148(2): 544-555.

4. Hao He*, Yan-ping Sun, Lei Zheng, Zheng-gang Yue, Steroidal saponins from Paris polyphylla Induce Apoptotic Cell Death and Autophagy in A549 Human Lung Cancer Cells, Asian Pacific Journal of Cancer Prevention, 2015, 16(3): 1169-1173.

5. Hao He*, Lei Zheng, Yan-ping Sun, Guang-wei Zhang, Zheng-gang Yue, Steroidal saponins from Paris polyphylla Suppress Adhesion, Migration and Invasion of Human Lung Cancer A549 Cells Via Down-regulating MMP-2 and MMP-9, Asian Pacific Journal of Cancer Prevention, 2014, 15(24): 10911-10916.

6. Li-xia Chen,Hao He, Feng Qiu*. Natural withanolides: an overview. Natural Product Reports. 2011, 28: 705-740.

7. Ling-he Zang,Hao He, Yuan-chao Ye, Wei-wei Liu, Si-miao Fam, Shin-ichi Tashiro, Satoshi Onodera, Takashi Ikejima*. Nitric Oxide Augments Oridonin-induced Efferocytosis by Human Histocytic Lymphoma U937 cells via Autophagy and the NF-κB-COX-2-IL-1 Pathway.Free Radical Research. 2012, 46: 1207-1219.

8.  Ling-he Zang,Hao He, Qian Xu, Yang Yu, Nan Zheng, Wei-wei Liu, Toshihiko Hayashi, Shin-ichi Tashiro, Satoshi Onodera, Takashi Ikejima*. Reactive oxygen species H2O2,OH, but not O2- promote oridonin-induced phagocytosis of apoptotic cells by human histocytic lymphoma U937 cells. International Immunopharmacology. 2013, 15(2): 414-423.

9. Yu-ze Li, Xin Wang,Hao He, Dong-dong Zhang, Yi Jiang, Xin-jie Yang, Fei Wang, Zhi-shu Tang, Xiao-mei Song*, Zheng-gang Yue*, Steroidal Saponins from the Roots and Rhizomes of Tupistra chinensis, Molecules, 2015, 20, 13659-13669.

10. Xiao-mei Song, Dong-dong Zhang,Hao He, Yu-ze Li, Xin-jie Yang, Chong Deng, Zhi-shu Tang, Jiu-cheng Cui, Zheng-gang Yue*, Steroidal glycosides from Reineckia carnea, Fitoterapia, 2015, 105, 240-245.

11. Yan Lou, Hui Zhang,Hao He, Kai-feng Peng, Ning Kang, Xing-chuan Wei, Xue-gai Li, Li-xia Chen, Xin-sheng Yao, Feng Qiu*. Isolation and Identification of Phase 1 Metabolites of Curcumol in Rats.Drug Metabolism and Disposition.2010, 38(11): 2014-2022.

12. Yan Lou, Feng Zhao,Hao He, Kai-feng Peng, Li-xia Chen, Feng Qiu*. Four New Sesquiterpenes from Curcuma wenyujin and Their Inhibitory Effects on Nitric-Oxide Production.Chemistry & Biodiversity.2010, 7: 1245-1253.

13. Yan Lou, Feng Zhao,Hao He, Kai-feng Peng, Xiao-hua Zhou, Li-xia Chen, Feng Qiu*. Guaiane-type Sesquiterpenes from Curcuma wenyujin and Their Inhibitory Effects on Nitric Oxide Production. Journal of Asian Natural Product Research.2009, 11: 737-747.

14. Wei-wei Liu, Wuxiyar Otkur, Ling-zhi Li, Qiong Wang,Hao He, Ling-he Zang, Toshihiko Hayashi, Shin-ichi Tashiro, Satoshi Onodera, Ming-yu Xia, Takashi Ikejima*. Interference of silibinin with IGF-1R signalling pathways protects human epidermoid carcinoma A431 cells from UVB-induced apoptosis.Biochemical and Biophysical Research Communications.2013, 432(2): 314-319.

15. Wei-wei Liu, Wuxiyar Otkur, Ling-zhi Li, Qiong Wang,Hao He, Yuan-chao Ye, Yu-ning Zhang, Toshihiko Hayashi, Shin-ichi Tashiro, Satoshi Onodera, Takashi Ikejima*. Autophagy induced by silibinin protects human epidermoid carcinoma A431 cells from UVB-induced apoptosis.Journal of Photochemistry and Photobiology B.2013, 123C: 23-31.

16.   Wei-wei Liu, Wuxiyar Otkur, Yu-ning Zhang, Qiu-yuan Li, Yuan-chao Ye, Ling-he Zang,Hao He, Toshihiko Hayashi, Shin-ichi Tashiro, Satoshi Onodera, Takashi Ikejima*. Silibinin protects murine fibroblast L929 cells from UVB-induced apoptosis through the simultaneous inhibition of ATM-p53 pathway and autophagy. FEBS Journal. 2013, 280(18): 4572-4584. 

17.  Li-xia Chen,Hao He, Gui-yang Xia, Kai-lan Zhou, Feng Qiu*. A new flavonoid from the aerial parts ofAndrographis paniculata.Natural Product Research. 2014, 28(3): 138-143.

获批国家专利:

1.  邱峰,何昊,池岛乔,陈丽霞,康宁。酸浆苦素A提取工艺及医药新用途(CN 103214497 B)。

2.   何昊。一种细胞冻存盒(ZL 201620291498.6)。

3.   何昊。一种实验室用便携冻存细胞复苏盒(ZL 201620291686.9)。

科研项目

(1)国家自然科学基金青年项目(81603265基于炎症和NF-κB信号通路的重楼皂苷抗肺癌体内药效物质基础及作用机制研究,主持

(2)陕西省教育厅科学研究计划项目(15JK1622重楼皂苷VII抗肺癌体内药效物质基础研究,主持

(3)西安医学院博士科研启动基金项目(2015DOC17基于炎症通路的重楼皂苷VII抗肺癌作用机制研究,主持

(4)大学生创新训练项目(201411840008重楼皂苷抗肺癌体内药效物质基础研究,指导教师

(5)国家自然科学基金面上项目(31270399酸浆属植物中多靶点抗雄激素非依赖性前列腺癌活性成分及其作用机制研究,参与

(6)陕西省教育厅科学研究计划项目(14JK1621基于组分结构理论大黄防治糖尿病肾病药效物质基础的研究,参与

(7)陕西省国际科技合作与交流计划项目(2015KW-048基于药物-药物相互作用(DDI)的抗结核药物协同增效机制研究,参与

(8)辽宁省教育厅科学研究计划项目(L2011177酸浆苦素类化合物抗非激素依赖性前列腺癌作用机制及构效关系研究,参与


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