郑蕾
来源:药物研究所 作者:药物研究所管理员 点击数: 发表时间:2016-11-15 15:00:04

郑蕾,女,1985年生,药物分析博士,西安医学院中药药理教研室教师。2007年毕业于吉林大学药学院药学专业,获医学学士学位;2009年毕业于吉林大学药学院药物化学专业,获医学硕士学位;2014年毕业于西安交通大学医学院,获药物分析博士学位,主要研究方向为药物体内作用过程分析、抗肿瘤药物筛选及药理学研究。参与国家自然科学基金、国家"十二五"重大新药创制专项和陕西省"青年科技新星配套项目等多项研究工作。在此期间,共发表SCI论文16篇,其中以第一作者发表SCI论文4篇,核心期刊1篇。

代表性论文

1. Lei Zheng, Yanmin Zhang, Yanping Liu, Xiaoyan Ou Yang, Yingzhuan Zhan,Momordica Cochinchinensis Spreng. seed suppresses breast cancer growth by arresting cell cycle and inducing apoptosis. Molecular medicine reports, 2015, 12(4): 6300-6310

2.  Lei Zheng, Yanmin Zhang, Yingzhuan Zhan, Changxiao Liu, Momordica cochinchinensis seed extracts suppress migration and invasion of human breast cancer ZR-75-30 cells via down-regulating MMP-2 and MMP-9, Asian pacific journal of cancer prevention, 2014, 15 (3): 1105-1110

3.   Lei Zheng, Xiaoli Wang, Wenjuan Luo, Yingzhuan Zhan, Yanmin Zhang,Brucine, an effective natural compound derived from nux-vomica, induces G1 phase arrest and apoptosis in LoVo cells, Food and chemical toxicology,2013, 58: 332-339

4.   Lei Zheng, Xu He, Weina Ma, Bingling Dai, Yingzhuan Zhan, Yanmin Zhang, Ta1722, an anti-angiogenesis inhibitor targeted on VEGFR-2 against human hepatoma, Biomedicine & pharmacotherapy,2012,66(7):499-505

5.   Yanmin Zhang,Lei Zheng, Jie Zhang , Bingling Dai , Nan Wang , Yinnan Chen , Langchong He, Antitumor activity of taspine by modulating the EGFR signaling pathway of Erk1/2 and Akt in vitro and in vivo, Planta medica,2011, 77(16):1774-1781

6.  Nan Wang,Lei Zheng, Yingzhuan Zhan, Yanmin Zhang, A novel taspine derivative suppresses human liver tumor growth and invasion in vitro and in vivo, Oncology Letters,2013, 6(3):855-859

7.  Weina Ma, Dongdong Zhang,Lei Zheng, Yingzhuan Zhan, Yanmin Zhang, Potential roles of Centipede Scolopendra extracts as a strategy against EGFR-dependent cancers, American journal of translational research,2015,7(1):39-52

8.  Wenjuan Luo, Xiaoli Wang,Lei Zheng,Yingzhuan Zhan,Dongdong Zhang,Jie Zhang, Yanmin Zhang, Brucine suppresses colon cancer cells growth via mediating KDR signalling pathway, Journal of cellular and molecular medicine,2013, 17(10):1316-1324

9.  Dongdong Zhang, Yanmin Zhang,Lei Zheng, Yingzhuan Zhan, Langchong He, Graphene oxide/poly-L-lysine assembled layer for adhesion and electrochemical impedance detection of leukemia K562 cancer cells, Biosensors and Bioelectronics, 2013, 15(42):112-118

10. Yanmin Zhang, Bingling Dai,Lei Zheng,Yingzhuan Zhan,Wanli W. Smith, Xiaoli Wang,Yinnan Chen, Langchong He, A novel angiogenesis inhibitor impairs lovo cell survival via targeting against human VEGFR and its signaling pathway of phosphorylation, Cell death & disease,2012, 3(10): e406.

11. Yali Zhou, Wenjuan Luo,Lei Zheng, Miao Li, Yanmin Zhang, Construction of recombinant FGFR1 containing full-length gene and its potential application, Plasmid, 2010, 64(1):60-67

12. Yan Zhang, Yanjun Cao, Qunli Wang,Lei Zheng, Jie Zhang, Langchong He, A potential calcium antagonist and its antihypertensive effects, Fitoterapia. 2011, 82(7):988-996

13. Huaizhen He, Nan Wang, Jie Zhang,Lei Zheng, Yanmin Zhang, Tas13D Inhibits Growth of SMMC-7721 Cell via Suppression VEGF and EGF Expression, Asian pacific journal of cancer prevention,2012, 13(5):2009-2014

14. Yingzhuan Zhan, Yanmin Zhang, Yinnan Chen, Nan Wang,Lei Zheng, Langchong He, Activity of taspine isolated from Radix et Rhizoma Leonticis against estrogen-receptor-positive breast cancer, Fitoterapia,2011, 82(6):896-902

15. Yingzhuan Zhan, Nan Wang, Cuicui Liu, Yinnan Chen,Lei Zheng, Langchong He, A novel taspine derivative, HMQ1611, suppresses adhesion, migration and invasion of ZR-75-30 human breast cancer cells, Breast cancer,2014, 21(3):334-340

16. Yingzhuan Zhan,Yanmin Zhang,Cuicui Liu,Jie Zhang,Wanli W. Smith,Nan Wang,Yinnan Chen,Lei Zheng,Langchong He,A novel taspine derivative, HMQ1611, inhibits breast cancer cell growth via estrogen receptor alpha and EGF receptor signaling pathways, Cancer preventionresearch, 2012, 5(6):864-873

17. 郑蕾,张彦民,对药乌头散的抗肿瘤活性筛选研究,中药材,2013368):1301-1304

18. 马维娜,何旭,郑蕾,张彦民,白藜芦醇对EGFR调控的肿瘤抑制作用及其机制,西安交通大学学报(医学版),2013234):185 -188

19. 郑蕾,张彦民,红参等复方汤剂抗肿瘤作用研究,第三届西部药物分析学术研讨会,陕西西安,2010202 -206

20. 代秉玲,张彦民,郑蕾,塔斯品碱衍生物的体外抗肿瘤活性筛选,第二届西部药物分析学术研讨会,2010202-206

授权发明专利

张彦民,贺浪冲,代秉玲,王楠,郑蕾,王嗣岑,张杰,一种新组织血管生成方法,2013.12.04,中国,CN102321568A

科研项目

(1)陕西省教育厅科学研究计划项目,16JK1666,中药木鳖子抗乳腺癌有效成分及作用机制研究,2016/06-2017/122万元,在研,主持。

(2)西安医学院博士科研启动基金项目,2015DOC18,中药木鳖子抑制血管生成有效成分筛选及作用研究,2015/07-2017/073万元,在研,主持。

(3)国家自然科学基金面上项目,8137008TaD1822调控EphB4/ephrinB2反向信号抑制肿瘤血管生成作用,2014/01-2017/12,70万,在研,第五参与人(FRET及荧光分析)。

(4)国家自然科学基金青年科学基金项目,81302800,基于ERαHER2的双靶点抑制剂TPDs逆转乳腺癌耐药作用及机制研究,2014/01-2016/1223万,在研,第二参与人(活体肿瘤成像模型构建)。

(5)国家自然科学基金青年科学基金项目,21305106,基于双功能化石墨烯非小细胞肺癌循环肿瘤细胞电化学传感新方法研究,2014/01-2016/1223万,在研,第二参与人(电化学生物传感器研制)。

(6)国家自然科学基金青年科学基金项目,81202494,新型塔斯品碱荧光探针与肿瘤细胞示踪成像分析研究,2013/01-2015/1224万,已结题,第二参与人(肿瘤细胞的培养与标记)。

(7)国家自然科学基金青年科学基金项目,81001447,双靶点VEGFR抑制剂TaD1611对肺癌组织血管生成作用研究,2011/01-2013/1220万,已结题,第四参与人(VEGFR拮抗性研究)。

 

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